BAF complex cooperates with c-Myc to orchestrate early fate decisions of CD8 T cells (Cut&Run)

We found cBAF and c-Myc co-assort asymmetrically to the two daughter nuclei, such that daughter cells with low c-Myc and cBAF display a cell fate trajectory towards memory T cell differentiation. Moreover, cBAF complex and c-Myc physically interact with each other, and act in establishing the chromatin landscape in activated CD8 T cells. Cut&Run analysis of 27 samples: Brg1, Arid1a and c-Myc binding sites were analyzed in first division Arid1a KO and WT CD8 T cells; c-Myc KO and WT activated CD8 T cells. 2 replicates for each group.