The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety

The 1,1-proton transfer reaction mechanism by alpha-methylacyl-CoA racemase is catalyzed by an aspartate/histidine pair and involves a smooth, methionine-rich surface for binding the fatty acyl moiety Descriptor: (S)-2-METHYLMYRISTOYL-COENZYME A, GLYCEROL, probable alpha-methylacyl-CoA racemase MCR Authors: Bhaumik, P, Wierenga, R.K. Deposit date: 2006-03-15 Release date: 2007-02-20 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.7 Å) Cite: The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface J.Mol.Biol., 367, 2007

α-甲基酰基辅酶A消旋酶（alpha-methylacyl-CoA racemase）所催化的1,1-质子转移反应机制由天冬氨酸/组氨酸对介导，该反应通过一处平整且富含甲硫氨酸的表面实现脂肪酰基基团的结合。
数据集描述符：(S)-2-甲基肉豆蔻酰辅酶A（(S)-2-METHYLMYRISTOYL-COENZYME A）、甘油（GLYCEROL）、推定型α-甲基酰基辅酶A消旋酶MCR（probable alpha-methylacyl-CoA racemase MCR）
作者：Bhaumik, P、Wierenga, R.K.
提交日期：2006-03-15
发布日期：2007-02-20
最后修改日期：2023-10-25
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7埃（1.7 Å）
引用文献：《α-甲基酰基辅酶A消旋酶催化的1,1-质子转移反应与脂肪酰基基团在疏水富含甲硫氨酸表面的移动相偶联》（原英文标题：The Catalysis of the 1,1-Proton Transfer by alpha-Methyl-acyl-CoA Racemase Is Coupled to a Movement of the Fatty Acyl Moiety Over a Hydrophobic, Methionine-rich Surface），发表于《Journal of Molecular Biology》（缩写：J.Mol.Biol.），2007年，第367卷。