cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody Descriptor: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1
COS-7 cells were transfected with wt TSHR or various mutant TSHRs. The vector pcDNA3.1(−) / hygromycin was used as a control. The TSHR is characterized by an elevated cAMP level compared to the contro
Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comp
Additional file 5: Table S2. Original data table for GPCR classification and ligand prediction in S. japonicum. In the table, the first column is the s.j GPCR genes ID, the second column is the GPCRs