RT-qPCR data tables.

Long noncoding RNAs (lncRNAs) play crucial roles in various cellular processes, including the response to oxidative stress. However, the relationship between oxidants and lncRNA expression remains poorly understood. This study investigated the effects of endogenous and exogenous prooxidants with reactive oxygen species (ROS)-generating activity on lncRNA expression in NIH3T3 cells. We treated cells with various compounds, including food-derived polyphenols and environmental pollutants, for 24 hours and analyzed lncRNA expression. Treatment with 1 μM exogenous prooxidants (1,2,4-benzenetriol or 1,4-naphthoquinone) resulted in a significant increase (>50-fold) in the expression of several lncRNAs, including Snhg4, Kcnq1ot1, Rmst, Neat1, Gt(ROSA)26Sor, and Peg13. Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-O-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (