The landscape of B cell receptor repertoires from COVID-19 patients by CDR3 sequencing of heavy and light chains

cells play vital roles in overcoming infection of respiratory syndrome coronavirus 2 (SARS-CoV-2). Although many studies have been investigated to elucidate the immune mecha-nism in COVID-19 patients, it is still unclear how B cell receptors (BCRs) constituents including heavy (IGHs) and light chains (IGL) respond to SARS-CoV-2 in patients with different symptoms. Here, we conducted the complementarity determining region 3 (CDR3) sequencing of IGHs and IGLs of COVID-19 patients and healthy controls.