Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators

Data accompanying the manuscript "Systematic Elucidation and Pharmacological Targeting of Tumor-Infiltrating Regulatory T Cell Master Regulators"-- includes RNA-Seq of sorted T-cell populations from patients across four tumor types, inferred T-cell ARACNe network, sgRNA counts matrices for pooled CRISPRko screen, PLATE-Seq of drug perturbational experiment, and single-cell RNA-Sequencing of spleen and tumor from gemcitabine-treated versus control mouse Tregs, as well code files used for data analysis.本数据集配套于学术论文《肿瘤浸润性调节性T细胞主调控因子的系统性阐明与药理学靶向研究》，包含以下内容：来自四种肿瘤类型患者的分选T细胞群体的RNA测序（RNA-Seq）数据、经推断得到的T细胞ARACNe调控网络、混合CRISPR敲除（CRISPRko）筛选的单引导RNA（sgRNA）计数矩阵、药物扰动实验的PLATE-Seq数据，以及吉西他滨处理组与对照组小鼠调节性T细胞（Tregs）的脾脏和肿瘤组织的单细胞RNA测序数据，同时附带用于数据分析的代码文件。