AcK-NFE2L2 binds the BCL2 gene
收藏reactome.org2025-03-25 收录
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NFE2L2 upregulates BCL2 expression and apoptotic cell death with implications in antioxidant protection, survival of cancer cells, and drug resistance. Mutagenesis and transfection assays identified an antioxidant response element between nucleotides -3148 and -3140 on the reverse strand of the Bcl-2 gene promoter that was essential for the activation of Bcl-2 gene expression (Niture et al 2012)
NFE2L2通过上调BCL2的表达和促进细胞凋亡，对抗氧化保护、癌细胞存活和耐药性具有影响。突变和转染实验揭示了位于Bcl-2基因启动子反向链上-3148至-3140核苷酸之间的抗氧化反应元件，该元件对于激活Bcl-2基因表达至关重要（Niture等，2012年）
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