An open-label randomized controlled trial to evaluate the efficacy of antihistamine premedication and infusion prolongation in prevention of hypersensitivity reaction to oxaliplatin.

Interventions: Additional intravenous chlorpheniramine 10 mg at 30 minutes before oxaliplatin infusion and oxaliplatin was given in a 3-hour intravenous infusion for all 6 planned cycles of FOLFOX/FOLFIRINOX regimens and 4 planned cycles of CAPOX regimen.,In control group, oxaliplatin was infused in two-hour duration. No adding chlorpheniramine in premedication.;Experimental Drug,Active Comparator Drug;CPM + prolongation oxaliplatin infusion ARM,Controlled ARM Primary outcome(s): incidence of hypersensitivity reaction during oxaliplatin infusion number of event, grade Study Design: Randomized