Crystal structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate

Protein Data Bank Japan2023-10-18 更新2026-04-19 收录

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Crystal structure of human hypoxanthine guanine phosphoribzosyltransferase in complex with (4S,7S)-7-hydroxy-4-((guanin-9-yl)methyl)-2,5-dioxaheptan-1,7-diphosphonate Descriptor: ({(2S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-[(2S)-2-hydroxy-2-phosphonoethoxy]propoxy}methyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase Authors: Guddat, L.W, Keough, D.T. Deposit date: 2021-09-22 Release date: 2022-05-18 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.58155523622 Å) Cite: Stereo-Defined Acyclic Nucleoside Phosphonates are Selective and Potent Inhibitors of Parasite 6-Oxopurine Phosphoribosyltransferases. J.Med.Chem., 65, 2022

人次黄嘌呤鸟嘌呤磷酸核糖基转移酶（hypoxanthine guanine phosphoribosyltransferase）与(4S,7S)-7-羟基-4-((鸟嘌呤-9-基)甲基)-2,5-二氧杂庚烷-1,7-二膦酸酯复合物的晶体结构配体描述：({(2S)-3-(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)-2-[(2S)-2-羟基-2-膦酰乙氧基]丙氧基}甲基)膦酸；次黄嘌呤-鸟嘌呤磷酸核糖基转移酶作者：Guddat, L.W、Keough, D.T. 存档日期：2021-09-22 发布日期：2022-05-18 最后修改日期：2023-10-18 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率为2.58155523622埃（Å）引用文献：《立体定向无环核苷膦酸酯是寄生虫6-氧代嘌呤磷酸核糖基转移酶的选择性强效抑制剂》，发表于《药物化学杂志》（J.Med.Chem.），第65卷，2022年

创建时间：

2021-09-22