Dataset related to the article: Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson's Disease: Triggers for Respiratory Rehabilitation?

Dataset related to the article: Vitacca, M.; Olivares, A.; Comini, L.; Vezzadini, G.; Langella, A.; Luisa, A.; Petrolati, A.; Frigo, G.; Paneroni, M. Exercise Intolerance and Oxygen Desaturation in Patients with Parkinson’s Disease: Triggers for Respiratory Rehabilitation? <em>Int. J. Environ. Res. Public Health</em> <strong>2021</strong>, <em>18</em>, 12298. Abstract: The role that oxygen desaturation plays in exercise tolerance and its rehabilitative implications<br> in patients with Parkinson’s disease (PD) are unclear. We aimed to test exercise tolerance and<br> oxygen saturation levels both during exercise and at night in PD patients to better define their rehabilitative<br> needs. In clinically stable PD patients, undergoing inpatient rehabilitation, and in “ON” phase,<br> we prospectively assessed clinical data, sleepiness, comorbidities, PD severity (Hoehn&amp;Yahr, HY),<br> motor function (ADLs, UPDRSII and UPDRSIII, Barthel Index, Functional Independence Measure),<br> balance, spirometry, respiratory muscles (MIP/MEP), peak cough expiratory flow (PCEF), continuous<br> night oxygen monitoring, and meters at 6MWT. Of 55 patients analyzed (28 with moderate–severe PD,<br> HY 2.5), 37% and 23% showed moderate–severe impairment on UPDRSII and UPDRSIII, respectively;<br> 96% had reduced exercise tolerance and severe respiratory muscles impairment (MIP/MEP<br> &lt; 45% pred.); 21.8% showed desaturations during exercise; and 12.7% showed nocturnal desaturations.<br> At multiple regression, low exercise tolerance and low mean nocturnal and exercise-induced<br> saturation correlated with several respiratory and motor function and disability indices (all p &lt;<br> 0.03). Exercise tolerance, exercise-induced desaturations, and nocturnal desaturations were extremely<br> frequent in PD patients and were worse in more severe PD patients. This suggests considering a<br> combined role for motor and respiratory rehabilitation in these patients.