Metabolome and microbiome multi-omics integration from a murine model of bronchopulmonary dysplasia

This study uses a neonatal mouse model of bronchopulmonary dysplasia (BPD) to examine the impact on the lung metabolome and microbiome. Lipopolysaccharide and hyperoxia were used as a double-hit approach to trigger lung inflammation and model BPD within the first two weeks of life. The study examines the impact of each exposure separately as well as their interaction, ultimately identifying putative metabolomic and microbiome-based biomarkers of stressors that can cause BPD. These data were then linked to a published transcriptome. Associations identified in this study have implications for the potential use of these biomarkers in clinical application and basic science research.