Circulating RNA: looking at the liver through a frosted glass

<i>Context</i>: The evaluation of the liver condition, based on serum enzymatic activity and biopsies, is insufficient. Therefore, it is a priority to find a correlation between circulating RNAs and liver damage. <i>Methods</i>: Publications were retrieved by the search terms “circulating RNA AND liver”. <i>Results</i>: Although differences exist between studies, a profile of RNAs that repeatedly appeared as indicators of liver damage was identified. <i>Discussion</i>: We highlight those circulating RNAs useful to diagnostic, and discuss the transport mechanisms. <i>Conclusion</i>: Several studies have proven that circulating RNAs are useful to establish a diagnostic and a prognosis of liver diseases.