Multivariable Cox regression analysis results for overall survival in the discovery and validation cohorts.

*The multivariable Cox regression model assuming the co-dominant genetic model contained the MTHFR Glu429Ala, ERCC5 His46His, SERPINE1 −675indelG, GSTM1 gene deletion genotypes as well as sex, age, stage and MSI status as covariates.**Only the multivariable Cox regression analysis result for the MTHFR Glu429Ala polymorphism when adjusted for sex, age, stage and MSI status is shown (assuming the dominant genetic model). The complete multivariable models for the dominant genetic model can be found in Tables S4 and S6 in File S1 for the discovery and validation cohorts.***The multivariable Cox regression analysis result for the MTHFR Glu429Ala polymorphism when adjusted for sex, age, stage and MSI status is shown (assuming the recessive genetic model). The complete multivariable models can be found in Tables S5 and S7 in File S1 for the discovery and validation cohorts. CI: confidence interval, HR: hazard ratio, n: number of patients, vs: versus.#The major homozygote genotypes and other referent categories are underlined.