CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c1(cc(nc2cc(nn12)c3c(nc4c(n3)cccc4)C)N5CC[C@H](C5)F)NC6CCOCC6, micromolar IC50=0.007291

Protein Data Bank Japan2024-10-16 更新2026-03-21 收录

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CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c1(cc(nc2cc(nn12)c3c(nc4c(n3)cccc4)C)N5CC[C@H](C5)F)NC6CCOCC6, micromolar IC50=0.007291 Descriptor: (8S)-5-[(3S)-3-fluoropyrrolidin-1-yl]-2-(3-methylquinoxalin-2-yl)-N-(oxan-4-yl)pyrazolo[1,5-a]pyrimidin-7-amine, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Gobbi, L, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人源磷酸二酯酶10与配体c1(cc(nc2cc(nn12)c3c(nc4c(n3)cccc4)C)N5CC[C@H](C5)F)NC6CCOCC6的晶体结构，该配体的微摩尔级半最大抑制浓度（IC₅₀）为0.007291。描述项：(8S)-5-[(3S)-3-氟吡咯烷-1-基]-2-(3-甲基喹喔啉-2-基)-N-(四氢吡喃-4-基)吡唑并[1,5-a]嘧啶-7-胺、镁离子、锌离子…… 作者：Joseph, C、Benz, J、Flohr, A、Gobbi, L、Rudolph, M.G. 沉积日期：2022-02-01 发布日期：2022-10-12 最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率2.29 Å）引用说明：《人源磷酸二酯酶10复合物晶体结构》待发表

创建时间：

2022-02-01