BIOCHEMICAL RESPONSES OF THE DREISSENA POLYMORPHA FROM MUNICIPAL POND TO CAFFEINE, MICROPLASTICS, AND HEATING IN SINGLE AND COMBINED EXPOSURES

Pharmaceuticals have become the aquatic pollutants
of growing concern. Caffeine is one of the most widely distributed in the
surface waters among them. However, the environmentally relevant
models of its effect, which include combined exposures with probable
confounding factors, are unknown. Microplastics are a suspected vector
that influences caffeine bioavailability. The temperature dependence of
response, considering the increase of temperature in surface waters, can
also be anticipated. The aim of this study was to analyze the input of
caffeine, microplastics and elevated temperature into their combined
effect on the zebra mussel Dreissena polymorpha (Pallas, 1771).

药物已成为日益受到广泛关注的水生污染物。其中，咖啡因是地表水中分布最为广泛的污染物之一。然而，目前尚未构建针对其环境相关效应的研究模型，尤其是纳入混杂因素联合暴露的效应模型仍属空白。微塑料（microplastics）被认为是影响咖啡因生物可利用性的潜在载体。此外，考虑到地表水水温呈上升趋势，生物响应的温度依赖性同样值得考量。本研究旨在探究咖啡因、微塑料与升温三者的联合暴露对斑马贻贝（*Dreissena polymorpha*，Pallas, 1771）的综合效应。