The DNA/RNA helicase DHX9 contributes to the transcriptional program of Androgen Receptor in prostate cancer.

Prostaste cancer (PC) is the most commonly diagnosed male malignancy and an important cause of mortality. Androgen signaling plays a key role in PC pathogenesis and the understanding of the mechanisms involved in the regulation of AR function might pave the ground for the development of more efficacious and long-lasting therapeutic strategies for PC patients. DNA/RNA helicases are emerging as important regulators of many cellular processes. Among them, DHX9 has been implicated in the control of genomic stability, transcription and DNA replication. To investigate the role of DHX9 in PC we perform RNA-sequencing analysis in androgen-sensitive LNCaP cells affects upon DHX9 silencing. Overall design: RNA-seq study of androgen-sensitive LNCaP cells knocked down for DHX9 to reveal DEGs upon DHX9 silencing.