Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the up conformation

Cryo-EM structure of the pancreatic ATP-sensitive potassium channel in the presence of carbamazepine and ATP with Kir6.2-CTD in the up conformation Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ATP-sensitive inward rectifier potassium channel 11 Authors: Shyng, S.L, Sung, M.W, Driggers, C.M. Deposit date: 2022-03-07 Release date: 2022-08-31 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Ligand-mediated Structural Dynamics of a Mammalian Pancreatic K ATP Channel. J.Mol.Biol., 434, 2022

结合卡马西平与ATP且Kir6.2-CTD处于向上构象的胰腺ATP敏感性钾通道的冷冻电镜（Cryo-EM）结构。描述符：腺苷-5'-三磷酸（ADENOSINE-5'-TRIPHOSPHATE）、ATP结合盒亚家族C成员8（ATP-binding cassette sub-family C member 8）、ATP敏感性内向整流钾通道11（ATP-sensitive inward rectifier potassium channel 11）。作者：Shyng, S.L.、Sung, M.W.、Driggers, C.M.。存档日期：2022-03-07；发布日期：2022-08-31；最后修改日期：2024-06-12。实验方法：电子显微镜（分辨率5.2埃）。引用文献：《哺乳动物胰腺KATP通道的配体介导结构动态》（Ligand-mediated Structural Dynamics of a Mammalian Pancreatic KATP Channel），《分子生物学杂志》（J.Mol.Biol.），2022年，第434卷。