Bright light increases the severity of seizure through activating the GABAergic projection from ventral lateral geniculate nucleus to superior colliculus

Light has diverse effects on human well-being, with intriguing connections to both physiological and pathological brain processes. Bright light induces an aberrantly high activity of vLGNGABA neurons, which inhibits the neuronal excitability of postsynaptic SC neurons and suppresses termination of generalized seizure. Combined with single nucleus transcriptomic and electrophysiological analysis, we wanted to identify key genes. There were two groups of mice, with fifteen mice in each group. The experimental group was intraperitoneally injected with kainic acid (30 mg/kg), while the control group was injected with physiological saline. After 14 days, tissue samples were taken from the bilateral ventrolateral geniculate nucleus (VLGN) brain regions of the mice for subsequent single-cell sequencing work.