Defining the microglia transcriptome during disease progression in ALS transgenic mice

ChEBI2013-07-15 更新2026-07-21 收录

ALS病理机制

胶质细胞转录组学

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Defining the microglia transcriptome during disease progression in ALS transgenic mice

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2013-07-15

Distinct amyloid-b and tau associated microglia profiles in Alzheimer's disease

阿尔茨海默病机制

胶质细胞转录组学

Alzheimer's disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-b and intraneuronal hyperphosphorylated, tau tangles and neuropil t

NIAID Data Ecosystem110

Transcriptome analysis of primary microglia defecting ASD-related genes.

自闭症分子机制

胶质细胞转录组学

We report the transcriptome analysis by RNAseq for primary microglia defecting ASD-related genes by siRNA treatment. Overall design: mRNA profiles of microglia after control, Chd8, and Tsc2 siRNA trea

NIAID Data Ecosystem10

Transcriptomic profiling of oligodendrocytes, astrocytes, and microglia in a cuprizone-induced demyelination model

脱髓鞘疾病模型

胶质细胞转录组学

Demyelination is a central pathological feature of multiple sclerosis and many other neurodegenerative diseases, and the cuprizone diet is a widely used model for studying this process. This study exa

NIAID Data Ecosystem00

ALS implicated protein TDP-43 sustains levels of STMN2 a mediator of motor neuron growth and repair. ALS implicated protein TDP-43 sustains levels of STMN2 a mediator of motor neuron growth and repair

ALS病理机制

修复治疗

The discovery that TDP-43 mutations cause familial ALS and that many patients display pathological TDP-43 mislocalization has nominated altered RNA metabolism as a potential disease mechanism. Despite

NIAID Data Ecosystem90

Loss of TREM2 reduces hyperactivation of progranulin deficient microglia but not lysosomal pathology [14 months]

额颞叶变性(FTLD)研究

胶质细胞转录组学

GRN haploinsufficiency causes frontotemporal lobar degeneration and results in microglial hyperactivation, lysosomal dysfunction and TDP-43 deposition. To understand the contribution of microglial hyp

Alliance of Genome Resources00

Defining the microglia transcriptome during disease progression in ALS transgenic mice

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