Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with N-9-(1',2',3',4'-Tetrahydroacridinyl)-1,8- diaminooctane at 2.4 angstroms resolution.

Structure of acetylcholinesterase (E.C. 3.1.1.7) complexed with N-9-(1',2',3',4'-Tetrahydroacridinyl)-1,8- diaminooctane at 2.4 angstroms resolution. Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, N-9-(1',2',3',4'-TETRAHYDROACRIDINYL)-1,8-DIAMINOOCTANE Authors: Brumshtein, B, Wong, D.M, Greenblatt, H.M, Carlier, P.R, Pang, Y.-P, Silman, I, Sussman, J.L. Deposit date: 2003-12-04 Release date: 2005-04-21 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Complexes of Alkylene-Linked Tacrine Dimers with Torpedo Californica Acetylcholinesterase: Binding of Bis(5)-Tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge. J.Med.Chem., 49, 2006

分辨率为2.4埃的乙酰胆碱酯酶（acetylcholinesterase, E.C. 3.1.1.7）与N-9-(1',2',3',4'-四氢吖啶基)-1,8-二氨基辛烷的复合物结构。描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、乙酰胆碱酯酶、N-9-(1',2',3',4'-四氢吖啶基)-1,8-二氨基辛烷。作者：Brumshtein, B、Wong, D.M、Greenblatt, H.M、Carlier, P.R、Pang, Y.-P、Silman, I、Sussman, J.L。提交日期：2003-12-04。发布日期：2005-04-21。最后修改时间：2024-10-16。实验方法：X射线衍射（2.4 Å）。引用文献：《亚烷基连接他克林二聚体与加利福尼亚电鳐乙酰胆碱酯酶的复合物：双(5)-他克林的结合引发活性位点峡谷的显著重排》，《药物化学杂志》（J.Med.Chem.），第49卷，2006年。