Gastrointestinal eradication of multiresistant gram negative bacteria by faecal microbiota transplantation (FMT). undefined

Managing recurrent urinary tract infection with resistant Gram-negative bacteria is an increasingly difficult clinical problem. Antibiotic therapy only provides temporary relief as infection recurs on antibiotic cessation. As multi-drug resistant bacterial infections become more prevalent in the community, antibiotic treatment options have become increasingly limited leaving only antibiotics that either have significant toxicity or must be delivered intravenously (or both). In those patients in whom the reservoir of infectious pathogens is likely to be in the gut, the ability to reduce pathogen carriage at this site has the potential to produce significant clinical benefit. In order to test the hypothesis that modulation of the gut microbiota can reduce the carriage of Gram-negative pathobionts in the gut and thus reduce recurrent infection by these organisms we designed a randomised controlled and double-blinded trial examining the ability of FMT to alter microbiota and reduce infection rates in persons with recurrent Gram-negative urinary tract infection.