Somatic cell hemoglobin and nitrogen oxide metabolism in human airway epithelium.

Supplementary Table 1 - Characteristics of SARP participants with available gene expression data stratified by Asthma status. Supplementary Table 2 - Multiple linear regression modeling the relationship between pre-BD FEV1PP (dependent variable) and sex Hemoglobin gene expression in bronchial epithelial cells, adjusting for age, sex, race and body mass index. Supplementary Figure 1 – Hemoglobin gene expression in bronchial epithelial cells strongly correlate with pre-bronchodilator percent of predicted FEV1 in asthmatics but not in controls enrolled in SARP I&II. Normalized gene expression is presented on a log 2 scale. R2 and p value are calculated using univariate linear regression.

补充表1 —— 按哮喘状态分层、且具备可用基因表达数据的SARP受试者特征。补充表2 —— 以支气管上皮细胞中pre-BD FEV1PP（因变量）与性别、血红蛋白基因表达的关联为建模对象的多元线性回归模型，校正了年龄、性别、种族与体质量指数。补充图1 —— 支气管上皮细胞中的血红蛋白基因表达与哮喘患者的支气管舒张前预测FEV1百分比呈显著相关，但在SARP I&II纳入的对照人群中未观察到此关联。归一化基因表达以log₂标度形式展示。R²与p值通过单变量线性回归计算获得。