Crystal Structure of YC-17-bound cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238

Crystal Structure of YC-17-bound cytochrome P450 PikC with the unnatural amino acid p-Acetyl-L-Phenylalanine incorporated at position 238 Descriptor: 4-{[4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY}-12-ETHYL-3,5,7,11-TETRAMETHYLOXACYCLODODEC-9-ENE-2,8-DIONE, Cytochrome P450 monooxygenase PikC, DI(HYDROXYETHYL)ETHER, ... Authors: Li, G.B, Pan, Y.J, Li, S.Y, Gao, X. Deposit date: 2022-03-21 Release date: 2023-02-15 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (2 Å) Cite: New mechanistic insight of cytochrome P450 PikC gained from site-specific mutagenesis by non-coding amino acids Nat Commun, 2023于238位掺入非天然氨基酸（unnatural amino acid）对乙酰基-L-苯丙氨酸（p-Acetyl-L-Phenylalanine）的YC-17结合态细胞色素P450 PikC晶体结构 描述项：4-{[4-(二甲基氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基]氧基}-12-乙基-3,5,7,11-四甲基氧杂环十二碳-9-烯-2,8-二酮、细胞色素P450单加氧酶（cytochrome P450 monooxygenase）PikC、二(羟乙基)醚（DI(HYDROXYETHYL)ETHER）等 作者：Li, G.B、Pan, Y.J、Li, S.Y、Gao, X. 提交日期：2022-03-21 发布日期：2023-02-15 最后修改日期：2023-11-29 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2埃（2 Å） 引用文献：《通过非编码氨基酸定点诱变获得细胞色素P450 PikC的新机制见解》，《自然·通讯》（Nat Commun），2023年