I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol

Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase aka phosphatase and tensin homolog (PTEN) dephosphorylates inositol 1,3,4,5-tetrakisphosphate (I(1,3,4,5)P4) to inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Maehama & Dixon 1998, Han et al. 2000).

磷脂酰肌醇-3,4,5-三磷酸3-磷酸酶及双特异性蛋白磷酸酶，亦称磷酸酶与张力蛋白同源物（PTEN），能够将肌醇1,3,4,5-四磷酸（I(1,3,4,5)P4）去磷酸化为肌醇1,4,5-三磷酸（I(1,4,5)P3)（Maehama & Dixon, 1998; Han et al., 2000）。