Genes significantly associated (p-6) with at least one trait in gene-based analyses focusing on loss-of-function (LoF) or predicted deleterious missense by M-CAP plus loss-of-function (MCAP+LoF).

Genes that meet gene-level significance after adjusting for multiple phenotypes (p-7) are highlighted in bold. Top trait: trait with the smallest p-value after meta-analysis adjusting for correlated metabolites. p-value (covs): p-value of meta-analysis (WES+WGS) after adjusting for correlated metabolites for top trait. If NA, this analysis was not performed for this trait due to no metabolic biomarkers meeting the criteria to be included as covariates in meta-analysis. p-value (raw): p-value of meta-analysis without adjusting for correlated metabolites for top trait. N WES: number of tested variants in WES. N WGS: number of tested variants in WGS. AC = Allele count. N overlap: number of variants present in both WES and WGS. N traits associated: number of traits that meet gene-wide significance after adjusting for multiple phenotypes (p-7), traits meeting standard gene-wide significance (2.5x10-6) in parenthesis. Driven by single variant?: Yes if after conditioning on top associated variant the meta-analysis association disappears (p>0.05). IDL-TG: Triglycerides in IDL. XS-VLDL-TG: Triglycerides in very small VLDL. Phe: Phenylalanine. His: Histidine. IDL-FC: Free cholesterol in IDL. IDL-P: Concentration of IDL particles. M-VLDL-L: Total lipids in medium VLDL. Gly:Glycine. XL-HDL-FC: Free cholesterol in very large HDL. IDL-CE %: Cholesterol esters to total lipids ratio in IDL. L-VLDL-FC %: Free cholesterol to total lipids ratio in large VLDL. XXL-VLDL-C %: Total cholesterol to total lipids ratio in extremely large VLDL.