Synthesis and Evaluation of a Carbosilane Congener of Ferroquine and Its Corresponding Half-Sandwich Ruthenium and Rhodium Complexes for Antiplasmodial and β‑Hematin Inhibition Activity
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https://figshare.com/articles/dataset/Synthesis_and_Evaluation_of_a_Carbosilane_Congener_of_Ferroquine_and_Its_Corresponding_Half_Sandwich_Ruthenium_and_Rhodium_Complexes_for_Antiplasmodial_and_Hematin_Inhibition_Activity/2038941
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资源简介：
A silicon-containing
congener of ferroquine (1) was
synthesized by incorporating an organosilicon motif in the lateral
side chain of ferroquine. Compound 1 was then further
reacted with dinuclear half-sandwich transition-metal precursors [Ru(Ar)(μ-Cl)Cl]2 (Ar = η6-p-iPrC6H4Me, η6-C6H6, η6-C6H5OCH2CH2OH), [Rh(COD)(μ-Cl)]2, and
[RhCp*(μ-Cl)Cl]2, to yield a series of heterometallic
organometallic complexes (2–6). Compound 1 coordinates selectively in a monodentate manner to the transition
metals via the quinoline nitrogen of the aminoquinoline scaffold.
All of the compounds were characterized using various analytical and
spectroscopic techniques, and the molecular structure of compound 1 was elucidated by single-crystal X-ray diffraction analysis.
Furthermore, the in vitro antiplasmodial activity
of compounds 1–6 was established
against the chloroquine-sensitive (NF54) and chloroquine-resistant
(Dd2) strains of the malaria parasite Plasmodium falciparum.
创建时间：
2015-12-17
