Liraglutide attenuates aluminum chloride-induced Alzheimer’s disease in rats by modulating the oxLDL/LPA/LPAR1 pathway.

Title: Liraglutide attenuates aluminum chloride–induced Alzheimer’s disease in rats by modulating the oxLDL/LPA/LPAR1 pathway
Description: This dataset supports the manuscript currently under review, which investigates the neuroprotective effects of liraglutide in a rat model of Alzheimer’s disease induced by aluminum chloride (AlCl₃). The study highlights the modulation of the oxLDL/LPA/LPAR1/BACE1 pathway as a novel mechanism of action.
Contents:
• Raw behavioral data (e.g., open field, Morris water maze, novel object recognition, etc.)
• Biochemical and neurochemical assay results (GSH, MDA, AChE, ELISA data for oxLDL, LPA, LPAR1, BACE1)
• Histopathological and immunohistochemical quantifications (e.g., NFTs % area, Aβ plaques/field, protein expression levels)
• Statistical analysis outputs (SPSS/GraphPad Prism files if applicable)
Methods Summary: Data were generated using validated behavioral tests, ELISA, histopathology, and immunohistochemistry in male Sprague-Dawley rats. Treatments included AlCl₃, liraglutide, and donepezil over 45 days.
Ethics: All animal procedures were approved by the Research Ethics Committee of the Faculty of Pharmacy, Mansoura University (Code: 2022--175).
This dataset is under embargo to align with the peer review process. It will be made publicly available upon manuscript acceptanc
License: CC-BY 4.0