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CTCF footprints on chromatin reveal impact of DNA methylation on its target search process at the single-molecule resolution

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We developed a novel method termed G-MAT that profiles the footprints of a nuclear protein on chromatin and DNA methylome simultaneously in living mammalian cells. Utilizing G-MAT to transcription factor CTCF, hundreds of proteins with distinct functions co-occupying CTCF binding sites on chromatin were found.

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2026-05-26
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