Structure of rat neuronal nitric oxide synthase heme domain in complex with 2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(2-(3- fluorophenyl)cyclopropylmethyl)ethan-1-amine

Protein Data Bank Japan2024-05-08 更新2026-03-21 收录

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Structure of rat neuronal nitric oxide synthase heme domain in complex with 2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(2-(3- fluorophenyl)cyclopropylmethyl)ethan-1-amine Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, N-{[(1R,2R)-2-(3-fluorophenyl)cyclopropyl]methyl}-2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethanamine, ... Authors: Li, H, Poulos, T.L. Deposit date: 2014-10-20 Release date: 2014-12-24 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.052 Å) Cite: Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015

大鼠神经元型一氧化氮合酶（neuronal nitric oxide synthase）血红素结构域与2-(2-(1H-咪唑-1-基)嘧啶-4-基)-N-(2-(3-氟苯基)环丙基甲基)乙-1-胺的复合物结构。组成描述：5,6,7,8-四氢生物蝶呤、乙酸根离子、N-{[(1R,2R)-2-(3-氟苯基)环丙基]甲基}-2-[2-(1H-咪唑-1-基)嘧啶-4-基]乙胺……作者：Li, H、Poulos, T.L. 存档日期：2014-10-20 发布日期：2014-12-24 最后修改日期：2024-05-08 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.052 Å）。引用文献：《新型2,4-二取代嘧啶类强效、选择性且细胞可透过性神经元型一氧化氮合酶抑制剂》，《药物化学杂志（J. Med. Chem.）》，58卷，2015年

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2014-10-20