Since loss of the NF2 tumor suppressor gene results in p21-activated kinase (Pak) activation, PAK inhibitors hold promise for the treatment of NF2-deficient tumors. To test this possibility, we asked

NIAID Data Ecosystem50

File S1 - MMP9 Processing of HSPB1 Regulates Tumor Progression

肿瘤分子机制

蛋白质功能调控

Contains the following: Figure S1. The effect of soluble HSPB1 on tumor transendothelial migration A. Transendothelial migration of HOS cells in the presence of HSPB1 or an HSPB1-neutralizing antibody

NIAID Data Ecosystem40

MeDIP-seq on heart tissues from AMI mouse models

疾病表观遗传学

甲基化组学动态分析

Alterations of DNA methylation modification in heart tissues of AMI mouse models at series of time points (Sham, AMI 10-min, 1-hr, 6-hr, 24-hr and 72-hr)

NIAID Data Ecosystem60

Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis [cell line]. Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis [cell line]

肿瘤分子机制

树突状细胞

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDCs). BPDCN occurs at least three times more frequently in men than women, but the reas

NIAID Data Ecosystem40