Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues

Fragment-based screening of HSP70 sheds light on the functional role of ATP-binding site residues Descriptor: (1S,2R,3R,5R)-3-(HYDROXYMETHYL)-5-((5-METHOXYQUINAZOLIN-4-YL)AMINO)CYCLOPENTANE-1,2-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BAG FAMILY MOLECULAR CHAPERONE REGULATOR 1, ... Authors: Jones, A.M, Westwood, I.M, Osborne, J.D, Matthews, T.P, Cheeseman, M.D, Rowlands, M.G, Jeganathan, F, Burke, R, Lee, D, Kadi, N, Liu, M, Richards, M, McAndrew, C, Yahya, N, Dobson, S.E, Jones, K, Workman, P, Collins, I, van Montfort, R.L.M. Deposit date: 2015-09-22 Release date: 2016-10-05 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.92 Å) Cite: A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms. Sci Rep, 6, 2016

基于片段的热休克蛋白70 (HSP70)筛选揭示三磷酸腺苷（ATP）结合位点残基的功能作用
描述项：(1S,2R,3R,5R)-3-(羟甲基)-5-((5-甲氧基喹唑啉-4-基)氨基)环戊烷-1,2-二醇、2-氨基-2-羟甲基-丙烷-1,3-二醇、BAG家族分子伴侣调节因子1等
作者：A.M.琼斯、I.M.韦斯特伍德、J.D.奥斯本、T.P.马修斯、M.D.奇斯曼、M.G.罗恩兰兹、F.杰格纳坦、R.伯克、D.李、N.卡迪、M.刘、M.理查兹、C.麦克安德鲁、N.亚希亚、S.E.多布森、K.琼斯、P.沃克曼、I.柯林斯、R.L.M.范蒙特福特
提交日期：2015-09-22
发布日期：2016-10-05
最后修改日期：2024-10-16
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.92埃（Å）
引用文献：《应用于高柔性靶点的基于片段策略：HSP70亚型抑制的研究进展与挑战》，《科学报告》（Sci Rep），第6卷，2016年