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Total Synthesis of 20-Norsalvinorin A. 1. Preparation of a Key Intermediate

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https://figshare.com/articles/dataset/Total_Synthesis_of_20_Norsalvinorin_A_1_Preparation_of_a_Key_Intermediate/2869948
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The key tricylic intermediate 3a, for the total synthesis of the C20-nor analogue of salvinorin A, was prepared in seven steps from 3-furaldehyde. Key steps involved a highly regio- and diastereoselective Lewis acid assisted Diels−Alder reaction followed by base-promoted epimerization and a completely stereoselective conjugate reduction.
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2016-02-26
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