Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution Descriptor: (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Frydenvang, K, Kastrup, J.S. Deposit date: 2015-12-22 Release date: 2016-03-02 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Tweaking Subtype Selectivity and Agonist Efficacy at (S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propionic acid (AMPA) Receptors in a Small Series of BnTetAMPA Analogues. J.Med.Chem., 59, 2016

分辨率为2.3 Å的GluA2配体结合结构域（S1S2J）与(S)-2-氨基-3-(5-(2-(3-氯苄基)-2H-四唑-5-基)-3-羟基异恶唑-4-基)丙酸复合物的晶体结构
描述符：(1S)-1-羧基-2-(5-{2-[(3-氯苯基)甲基]-2H-四唑-5-基}-3-氧代-2,3-二氢-1,2-恶唑-4-基)乙-1-铵、1,2-乙二醇、氯离子……
作者：Frydenvang K、Kastrup J.S.
提交日期：2015-12-22
发布日期：2016-03-02
最后修改日期：2024-11-13
实验方法：X射线衍射（2.3 Å）
引用文献：《在一系列小型BnTetAMPA类似物中调控(S)-2-氨基-3-(3-羟基-5-甲基-4-异恶唑基)丙酸（α-氨基-3-羟基-5-甲基-4-异恶唑丙酸，AMPA）受体的亚型选择性与激动剂效能》，《药物化学杂志》，第59卷，2016年