Cell mortality grades and metabolic deviation grades of essential genes for each consensus molecular subtype, obtained using DMEM medium.

N/D is obtained from the DepMap portal (https://depmap.org/portal/) and is defined as the ratio of the cell death number (N) and the total number of colon cancer cell lines (D) used in the experimental test. “No.Drugs” denotes the number of drugs retrieved from DrugBank (https://go.drugbank.com/) that modulate each gene. “SE.Score” denotes the side effect score, calculated using average adverse events. “—” indicates that data were not available on the databases. “*” indicates that ADSS2 and CTPS1 are the representative of duplicate enzymes (ADSS1 and ADSS2) and (CTPS1 and CTPS2), respectively.