CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 16

CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 16 Descriptor: 5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amine, Mitogen-activated protein kinase kinase kinase 12 Authors: Zebisch, M, McEwan, P.A, Barker, J.J, Cross, J.B. Deposit date: 2023-04-24 Release date: 2023-07-26 Last modified: 2024-06-19 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy. J.Med.Chem., 66, 2023化合物16与双亮氨酸拉链激酶（DLK）复合物的晶体结构 描述符：5-[1-(3-吗啉-4-基-1-双环[1.1.1]戊基)-2-异丙基-咪唑-4-基]-3-(三氟甲氧基)吡啶-2-胺；丝裂原活化蛋白激酶激酶激酶12 作者：Zebisch, M.、McEwan, P.A.、Barker, J.J.、Cross, J.B. 存入日期：2023-04-24 发布日期：2023-07-26 最后修改日期：2024-06-19 测试方法：X射线衍射（分辨率1.95埃） 引用文献：《IACS-52825的发现：一种用于治疗化疗诱导性周围神经病变的强效选择性DLK抑制剂》，《药物化学杂志》，第66卷，2023年