Aerobic Copper-Mediated Domino Three-Component Approach to 2‑Aminobenzothiazole Derivatives

An unprecedented
three-component reaction involving a 2,2′-diaminodiaryl
disulfide, copper cyanide, and an electrophile is described. This
transformation is based on an oxidative copper-mediated S-cyanation
as a key step and involves a cyanation/cyclization/acylation domino
sequence enabling a rapid and efficient synthesis of diversely substituted
2-aminobenzothiazole derivatives. Notably, this reaction proceeds
via an original mechanism involving an intermolecular migration of
the acyl group.