Precise 5' splice site recognition is essential for both constitutive and regulated pre-mRNA splicing. The U1 snRNP specific protein U1C is involved in this first step of spliceosome assembly and impo

NIAID Data Ecosystem50

Transcriptome analysis of zebrafish heart exposed to sorafenib

药物心脏毒性

斑马鱼基因功能

Sorafenib is associated with cardiac adverse effects, including left ventricular dysfunction. However, the precise mechanism remains unclear. Here, we aimed to establish the genes responsible for this

NIAID Data Ecosystem20

Notoginsenoside R1 regulates ischemic myocardial lipid metabolism through activating AKT/mTOR signaling pathway

mTOR信号通路

缺血性心脏病治疗

Radix notoginseng is widely used to treat ischemic heart disease in China and other Asian countries, and notoginsenoside R1 (NGR1) is its characteristic and large-amount ingredient. However, the poten

NIAID Data Ecosystem70

Omipalisib Inhibits Esophageal Cancer Growth through PI3K/AKT/mTOR Signalling Pathway Disruption. Omipalisib Inhibits Esophageal Cancer Growth through PI3K/AKT/mTOR Signalling Pathway Disruption

食管鳞癌

mTOR信号通路

Esophageal squamous cell carcinoma (OSCC) is a lethal digestive tract malignancy with limited effective interventions. This study aims to explore a new potential inhibitor on OSCC and investigate the

NIAID Data Ecosystem40

RNA-seq of depdc5-/-, tsc2-/-, depdc5-/- x tsc2-/- and wildtype zebrafish larvae

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