Genes-Environments and Admixture in Latino Asthmatics (GALA II) Study

A case-control pharmacogenetic study of bronchodilator drug response among racially admixed Latino children with asthma. Each participant had two spirometry measurements using the KoKo PFT System. With the first spirometry test, participant was administered with 4 puffs of HFA Albuterol. The second albuterol measurement was based on age, for participants under 16 years of age, additional 2 puffs were administered and for those over 16 years of age, additional 4 puffs were administered. The overall goal is to identify genetic factors which are predictive of drug response in children with asthma. The principal tools include a questionnaire and biological specimen collection. Participants are 8-21 years old at time of recruitment. Children with asthma have physician-diagnosed asthma, symptoms and medications. The GALAII Study is utilized in the following dbGaP substudies. To view genotypes, analysis, other molecular data, and derived variables collected in these substudies, please click on the following substudies below or in the "Substudies" box located on the right hand side of this top-level study page phs001180 GALAII Study. phs001274phs001274 GALAII GWAS ]]>
Eligibility for Cases Subjects meeting the following criteria will be eligible for participation: Ages between 8 and 21 years old Parents and Grandparents of the same ethnicity [self-identified] History of asthma [physician diagnosed or currently taking asthma medication] Having experienced symptoms of coughing, wheezing or shortness of breath in the past 2 years No respiratory infections for ≥ 6 weeks No asthma exacerbations for ≥ 6 weeks ≤ 10 pack year smoking history, no smoking in the last year If pregnant, < 3rd trimester No other history of lung diseases Eligibility - Healthy Controls Subjects meeting the following criteria will be eligible for participation: Ages between 8 and 21 years old Parents and Grandparents of Latino ethnicity [self-identified] No history of asthma No history or report of ever having experienced symptoms of coughing, wheezing or shortness of breath ≤ 10 pack year smoking history, no smoking in the last year No other history of lung diseases or chronic illness ]]>
Time Line February 2006 - first qualifying participant February 2012 and February 2015 - Genome Wide Association sequencing December 2014 - Whole Genome Sequencing - dbGaP Substudy "NHLBI WGS: Gene-Environment, Admixture and Latino Asthmatics (GALAII) Study" ]]>