Single-nucleus RNA Sequencing of Kidney and Brain Samples from Young WT and Klotho KO Male Mice

This dataset includes single-nucleus gene expression profiles from kidney and cerebral cortex samples of a young male C57BL/6J mouse with a-klotho gene knockout, along with the age-matched wild-type control. This short-lived model was used to validate transcriptomic clocks and to comprehensively characterize the molecular hallmarks of mortality associated with this genetic modification. Overall design: Young (8-week-old) male wildtype (WT) and a-klotho knockout (Klotho KO) C57BL/6J mice. 4 biological replicates: 1 kidney and 1 brain sample per genotype.