CpG Island Structure and Trithorax/Polycomb Chromatin Domains in Human Cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=e831ce08c737955e394533cdedc3e905
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资源简介：
TrxG and PcG complexes play key roles in the epigenetic regulation of development through H3K4me3 and H3K27me3 modification at specific sites throughout the human genome, but how these sites are selected is poorly understood. We find that in pluripotent cells, clustered CpG islands at genes predict occupancy of H3K4me3 and H3K27me3, and these "bivalent" chromatin domains precisely span the boundaries of CpG island clusters.
提供机构：
Whitehead Institute for Biomedical Research
创建时间：
2022-02-20
