HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 6a ANDINDAZOLE ACID BOUND IN H12-POCKET

HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA (RORC2) LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 6a ANDINDAZOLE ACID BOUND IN H12-POCKET Descriptor: 4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-4-fluoro-1H-indazol-3-yl}-3-fluorobenzoic acid, N-(3-{[(3S)-4-(cyclopentanecarbonyl)-3-methylpiperazin-1-yl]methyl}-5-fluoro-2-methylphenyl)-4-fluorobenzene-1-sulfonamide, Nuclear receptor ROR-gamma Authors: Vajdos, F.F. Deposit date: 2022-11-29 Release date: 2023-03-01 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.18 Å) Cite: Macrocyclic Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonists. Acs Med.Chem.Lett., 14, 2023人维甲酸相关孤儿受体γ（RORC2）配体结合域与化合物6a及结合于H12口袋的吲唑酸复合物。描述符：4-{1-[2-氯-6-(三氟甲基)苯甲酰基]-4-氟-1H-吲唑-3-基}-3-氟苯甲酸、N-(3-{[(3S)-4-(环戊烷羰基)-3-甲基哌嗪-1-基]甲基}-5-氟-2-甲基苯基)-4-氟苯-1-磺酰胺、核受体RORγ（Nuclear receptor ROR-gamma）。作者：Vajdos, F.F.。存入日期：2022-11-29。发布日期：2023-03-01。最后修改日期：2024-11-13。实验方法：X射线衍射（分辨率2.18埃）。引用文献：《大环类视黄酸受体相关孤儿受体C2反向激动剂》，《Acs Med.Chem.Lett.》，第14卷，2023年。