Replication data for - Inflammation and hemostasis in loiasis before and after ivermectin treatment: a biological pilot cross-sectional study

Recent epidemiologic data suggested an increased mortality and morbidity in individuals harboring high densities of Loa loa microfilariae in the blood, underscoring the importance of studies on the possible reasons for this excess mortality. As part of the MorLo project, this cross-sectional study assessed blood samples from 38 people living in an area of Cameroon where loiasis is endemic. We evaluated the impact of loiasis and its treatment with ivermectin on hematological, hemostatic, and biochemical blood parameters (complete blood counts, erythrocyte sedimentation rate, C-reactive protein, prothrombin time, activated thromboplastin time, fibrinogen, serum protein electrophoresis, ferritin, D-dimers, prothrombin fragment F1+2 and plasminogen). Participants were divided into four balanced groups based on their Loa loa microfilarial densities. At baseline, eosinophils (p<0.001) and platelets (p=0.044) increased with microfilarial densities. At day 4 following ivermectin administration, median eosinophils rose from 171/µL to 1,095/µL (p<0.001) and median D-dimers increased from 582 ng/mL to 745 ng/mL (p=0.024) with a median relative variation of +34.7%. C-reactive protein, fibrinogen, and alpha-1-globulin also increased significantly after treatment. Ivermectin treatment appeared to induce inflammation, coagulation activation and fibrinolysis.

近期流行病学数据表明，血液中携带高密度洛阿洛阿微丝蚴的个体死亡率和发病率有所上升，凸显了探究导致死亡率超常的可能原因的研究重要性。作为MorLo项目的组成部分，本研究为一项横断面调查，评估了居住在喀麦隆洛阿洛阿病流行地区的38人的血液样本。我们评估了洛阿洛阿病及其用ivermectin治疗对血液学、血液凝固和生化血液参数（全血计数、红细胞沉降率、C反应蛋白、凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、血清蛋白电泳、铁蛋白、D-二聚体、凝血酶原片段F1+2和纤溶酶原）的影响。参与者根据其洛阿洛阿微丝蚴密度分为四个均衡的组别。在基线时，嗜酸性粒细胞（p<0.001）和血小板（p=0.044）随着微丝蚴密度的增加而升高。在ivermectin给药后的第4天，嗜酸性粒细胞的平均数量从171/µL上升至1,095/µL（p<0.001），中位D-二聚体水平从582 ng/mL上升至745 ng/mL（p=0.024），平均相对变化率为+34.7%。C反应蛋白、纤维蛋白原和α-1-球蛋白在治疗后也显著增加。ivermectin治疗似乎可诱导炎症、凝血激活和纤溶作用。