Host dysosmia in SARS-CoV-2 infection

The respiratory condition COVID-19 arises in a human host upon the infection with SARS-CoV-2, a coronavirus that was first acknowledged in Wuhan, China, at the end of December 2019 after its outbreak of viral pneumonia. The full-blown COVID-19 can lead, in susceptible individuals, to premature death because of the massive viral proliferation, hypoxia, misdirected host immunoresponse, microthrombosis, and drug toxicities. Alike other coronaviruses, SARS-CoV-2 has a neuroinvasive potential, which may be associated with early neurological symptoms. In the past, the nervous tissue of patients infected with other coronaviruses was shown to be heavily infiltrated. Patients with SARS-CoV-2 commonly report dysosmia, which has been related to the viral access in the olfactory bulb. However, this early symptom may reflect the nasal proliferation that should not be confused with the viral access in the central nervous system of the host, which can instead be allowed by means of other routes for spreading in most of the neuroanatomical districts. The dataset was used to write the hypothesis "Disentangling the Hypothesis of Host Dysosmia and SARS-CoV-2: The Bait Symptom That Hides Neglected Neurophysiological Routes", which was published by the Journal Frontiers in Physiology in 2020.

COVID-19，一种呼吸系统疾病，源于人类宿主感染SARS-CoV-2冠状病毒，该病毒首次于2019年12月底在中国武汉爆发，引发病毒性肺炎。在易感个体中，重症COVID-19可能导致因病毒大量增殖、缺氧、宿主免疫反应误导向、微血栓形成和药物毒性等因素导致的过早死亡。与其它冠状病毒相似，SARS-CoV-2亦具有神经侵袭性潜能，可能与其早期神经症状相关。既往研究表明，感染其他冠状病毒的患者神经组织常被严重浸润。SARS-CoV-2感染者通常会出现嗅觉减退，这与病毒进入嗅球有关。然而，这一早期症状可能反映了鼻内的病毒增殖，不应与病毒进入宿主中枢神经系统的途径相混淆，后者可以通过其他途径在大多数神经解剖区域传播。该数据集被用于撰写假设《解构宿主嗅觉异常与SARS-CoV-2之谜：隐藏被忽视神经生理学途径的诱饵症状》，该假设于2020年由《生理学前沿》杂志发表。