CHD1 Alters Sensitivity to Aurora Kinase A Inhibitors. CHD1 Alters Sensitivity to Aurora Kinase A Inhibitors

In this study, we sought to understand the impact of CHD1 on sensitivity to Aurora A inhibitors in prostate and other cancers and underlying mechanisms Overall design: WT and CHD1 KO BPH1 cells were treated with DMSO or Alisertib (10μM) for 24 hours. Then, cells were lysed with TRIzol, followed by RNA extraction. Experiment was performed in triplicate. RNA-Sequencing was performed by UT MD Anderson Science Park NGS Core.