Frequency in human tumours and functional impairment of some experimentally induced mutants.

The table shows the 14 mutants induced by acetaldehyde (Ac), B[a]P or AFB1 for which exhaustive functional data were available from Dearth et al.[12].(1)The number refers to the identity of the mutant in the corresponding paper: Ac, table 3 from [15]; AFB1, table 3 from [16]; B[a]P, table 2 from the present work.(2)According to Dearth et al.[12].(3)According to IARC database R14.(4)++: loss of transcriptional activity on the 22 p53 DBS tested; +: loss of transcriptional activity on 13 DBS only [12].(5)++: DNE on the 11 DBS tested; +: DNE on more than 5 DBS; +/−: DNE on 3 DBS only; −: no DNE [12].