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Cooperative Associations with Sites on Different Nucleosomes Mediate Heterochromatin Spreading

Alliance of Genome Resources2026-08-01 收录

异染色质扩散机制

SIR复合物功能

数据链接：

https://www.yeastgenome.org/dataset/GSE76553 数据链接链接失效反馈

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资源简介：

Sir3wH and Sir4CC are required for SIR complex spreading in vivo but play partially redundant roles when Sir3 is overexpressed.

应用场景：

表观遗传调控

异染色质扩散机制

Crucial mechanisms are required to restrict self-propagating heterochromatin spreading within defined boundaries and prevent euchromatic gene silencing. In the filamentous fungus Neurospora crassa, th

NIAID Data Ecosystem30

The histone chaperone FACT facilitates heterochromatin spreading through regulation of histone turnover and H3K9 methylation states

异染色质扩散机制

组蛋白分子伴侣FACT功能

Heterochromatin formation requires several steps involving: nucleation followed by spreading of large, silent domains and its faithful re-establishment and maintenance after each replication cycle. Th

NIAID Data Ecosystem10

Local chromatin context dictates the genetic determinants of the heterochromatin spreading reaction.

异染色质扩散机制

表观遗传调控

Heterochromatin spreading, the expansion of gene-silencing structures from DNA-encoded nucleation sites, occurs in distinct settings. Spreading re-establishes gene-poor constitutive heterochromatin ev

NIAID Data Ecosystem20

Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading.. Phosphorylation of HP1/Swi6 relieves competition with Suv39/Clr4 on nucleosomes and enables H3K9 trimethyl spreading.

异染色质扩散机制

组蛋白H3K9甲基化

Heterochromatin formation in Schizosaccharomyces pombe requires the spreading of histone 3 (H3) Lysine 9 (K9) methylation (me) from nucleation centers by the H3K9 methylase, Suv39/Clr4, and the reader

NIAID Data Ecosystem00

Cooperative Associations with Sites on Different Nucleosomes Mediate Heterochromatin Spreading

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