Additional file 3 of Single-cell profiling reveals a reduced epithelial defense system, decreased immune responses and the immune regulatory roles of different fibroblast subpopulations in chronic atrophic gastritis

Supplementary Material 3: Additional file 3: Figure S3. Changes in the expression of TLRs, the chemokine system and metabolic activities in macrophages. (A) Violin plot showing the differences in the gene signature scores of chemokines and Toll-like receptors between CAG and control samples. P values were calculated via the two-sided Wilcoxon test. ****, p < 0.0001. (B) Proportion of TLR-expressing C1Q+ macrophages in CAG and control samples. (C) Feature plot showing TLR expression levels in C1Q+ macrophages in CAG samples. (D) Feature plot showing the expression levels of MMPs and TIMPs in C1Q+ macrophages in CAG samples. (E) Bubble plot showing metabolic activity analysis of C1Q+ macrophages between CAG and control samples. The circle size and color darkness both represent the scaled metabolic score. The red on the bubble plot shows the top increased metabolic pathways, and the blue shows the top decreased metabolic pathways. (F) Boxplots showing the metabolic scores of nitrogen metabolism and glycerophospholipid metabolism. P values were calculated via the two-sided Wilcoxon test. ns, not significant, **, P < 0.01 and ****, P < 0.0001. (G) Feature plot showing LDLR expression levels in C1Q+ macrophages between CAG and control samples.