PrEP clinical effectiveness and cost-effectiveness in selected scenarios.

For non base-case scenarios, 95% uncertainty range was determined by holding the relevant user-determined parameters (e.g. condom use, PrEP adherence) fixed and conducting probabalistic uncertainty analysis with all other parameters.Abbreviations: UR: Uncertainty range; CS: Cost saving.aSee Table 1 for sensitivity range for PrEP relative risk reduction.bNumber needed to treat to prevent 1 HIV infection.c15% decrease in condom use, increase in STI prevalence and increase in sexual frequency.dMonogamous serodiscordant relationship with the HIV positive partner taking antiretroviral therapy.PrEP clinical effectiveness and cost-effectiveness in selected scenarios.