Crystal structure of Ubiquitin Carboxy Terminal Hydrolase L1 Q209C mutant covalently crosslinked to ubiquitin genetically encoded with N6-(6-bromohexanoyl)-L-lysine

Crystal structure of Ubiquitin Carboxy Terminal Hydrolase L1 Q209C mutant covalently crosslinked to ubiquitin genetically encoded with N6-(6-bromohexanoyl)-L-lysine Descriptor: HEXANOIC ACID, Polyubiquitin-C, Ubiquitin carboxyl-terminal hydrolase isozyme L1 Authors: Pannala, N, Patel, R, Das, C. Deposit date: 2025-04-08 Release date: 2025-07-30 Last modified: 2025-12-03 Method: X-RAY DIFFRACTION (2 Å) Cite: Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases. Chembiochem, 26, 2025

泛素羧基末端水解酶L1（Ubiquitin Carboxy Terminal Hydrolase L1）Q209C突变体与经N6-(6-溴己酰基)-L-赖氨酸（N6-(6-bromohexanoyl)-L-lysine）基因编码的泛素共价交联的晶体结构
描述项：己酸（HEXANOIC ACID）、多聚泛素-C（Polyubiquitin-C）、泛素羧基末端水解酶同工型L1（Ubiquitin carboxyl-terminal hydrolase isozyme L1）
作者：Pannala, N、Patel, R、Das, C.
提交日期：2025-04-08
发布日期：2025-07-30
最后修改日期：2025-12-03
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2埃（2 Å）
引用文献：《用于共价捕获与去泛素化酶抑制的内源泛素亲电试剂》（Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases），《Chembiochem》，第26卷，2025年