Discovery of Pyrrolidine-based b-Secretase Inhibitors: Lead Advancement through Conformational Design for Maintenance of Ligand Binding Efficiency
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Discovery of Pyrrolidine-based b-Secretase Inhibitors: Lead Advancement through Conformational Design for Maintenance of Ligand Binding Efficiency Descriptor: (1R,4'S)-3,4-dihydro-2H-spiro[naphthalene-1,3'-pyrrolidin]-4'-yl[(2S,4R)-2,4-diphenylpiperidin-1-yl]methanone, Beta-secretase 1, GLYCEROL, ... Authors: Allison, T, Munshi, S, Soisson, S.M. Deposit date: 2011-11-01 Release date: 2012-01-18 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of pyrrolidine-based beta-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency. Bioorg.Med.Chem.Lett., 22, 2012
基于吡咯烷的β-分泌酶抑制剂发现：通过构象设计推进先导化合物以维持配体结合效率
配体结合效率描述符：(1R,4'S)-3,4-二氢-2H-螺[萘-1,3'-吡咯烷]-4'-基[(2S,4R)-2,4-二苯基哌啶-1-基]甲酮、β-分泌酶1（Beta-secretase 1）、甘油（GLYCEROL）等
作者：Allison T、Munshi S、Soisson S.M.
存储日期：2011-11-01
发布日期：2012-01-18
最后修改日期：2024-10-30
检测方法：X射线衍射（1.9 Å）
参考文献：基于吡咯烷的β-分泌酶抑制剂发现：通过构象设计推进先导化合物以维持配体结合效率，《Bioorg.Med.Chem.Lett.》，22卷，2012年
创建时间：
2011-11-01
